Alcohol-Related Neurologic Disease: Types, Signs, Treatment

N-acetylcysteine may have application in the prevention or treatment of neuropathy. Rats with experimentally-induced diabetes for 2 months had a 20% reduction in nerve conduction velocity and 48% reduction in endoneurial blood flow. A mechanism of cisplatin chemotherapy-induced peripheral neuropathy was elucidated in an in vitro mouse model. Apoptosis of neurones was induced by cisplatin, but pre-incubation with N-acetylcysteine completely blocked apoptosis [112]. Among patients with chronic alcohol use disorder, neuropathy is the most common harmful sequelae.

Management of alcohol-induced peripheral neuropathy

Usually, when sensory function becomes impaired above the ankle, they will also spread into the hands, a distribution known as the stocking-and-glove pattern.[5] Symptoms also often develop symmetrically. However, vulnerability to neuropathy and its severity and speed of progression varies. Women, continuous as opposed to episodic drinkers, and people with a family history of the disorder appear to be more vulnerable to alcoholic alcohol neuropathy stages neuropathy and more severe presentations. This review focuses on the many pathways that play a role in the onset and development of alcohol-induced neuropathy, as well as present the possible treatment strategies of this disorder, providing insights into a further search of new treatment modalities. Thus, there is a need to screen acetyl-L-carnitine in both preclinical and clinical models of alcoholic neuropathy.

Alcohol addiction treatment

It was observed that abstinence may lead to the regression of several symptoms of AAN [159]. As yet there is no effective therapeutic intervention available for relieving the neuropathic pain due to chronic alcohol consumption. Izumi et al. [73] also demonstrated that a single day of ethanol exposure in rats on post natal day 7 results in significant apoptotic neuronal damage throughout the forebrain after 24 h of ethanol administration. Thus, it is quite possible that chronic alcohol consumption is responsible for inducing neuropathy by activation of the caspase cascade and may be an important target for the treatment of alcoholic neuropathy. One of the other important issues in alcoholic individuals is the source of their calorie intake. These individuals draw the majority of calories from calorie rich alcoholic beverages with low nutritive value.

Malnutrition and Micronutrients Deficiency

This study is reported in accordance with the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines [7]. Statistical calculation of pooled proportions was conducted in R language, using the default settings of the “meta” package and the “metaprop” function with a random effects model [8]. When significantly limiting or cutting off alcohol consumption, receiving ongoing support is essential. People with a lengthy history of alcohol misuse might experience loss of balance, pain, tingling, weakness, or numbness after drinking alcohol. The total number of axons was estimated directly with the physical fractionator method (Gundersen, 1986, Mayhew and Olsen, 1991). This method consists of distribution from counting fields which are systematically and evenly displaced (in a SURS way) on the whole nerve cross-section.

Functional Observational Battery (FOB)

• It may also be that comorbid hepatic dysfunction is a risk factor for alcohol-related peripheral neuropathy.
• They get worse with more alcohol consumption, so if you stop drinking and seek professional medical attention, you can manage the symptoms of the disorder and potentially keep the nerve damage from worsening.
• Learn how to recognize the signs and symptoms so you can connect patients with the resources they need.
• The morphological basis of post-alcoholic damage of neural tissue includes primary axonopathy and secondary demyelination of motor and sensory (especially small) fibers [105].
• Regarding the other parameters, lacrimation, pupil reflex, palpebral closure, salivation and breathing, there was no significant difference between animals.